Guanethidine sulfate (Guanethidine monosulfate，硫酸胍乙啶)

Guanethidine sulfate (Guanethidine monosulfate), an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sulfate enters noradrenergic nerve terminals by the neuronal amine carrier^[1][2].

Guanethidine sulfate（5-40 mg/kg；腹膜内注射；每日；4-28 天；雄性 Wistar 大鼠）以 40 mg/kg 治疗 28 天会导致不完全交感神经切除，并伴有对去甲肾上腺素的部分不可逆超敏反应，而 5 mg/kg 不会引起组织学或永久性血流动力学变化^[2]。

Guaethidine sulfate (5-40 mg/kg; intraperitoneal injection; daily; 4-28 days; male Wistar rat) treats 40 mg/kg for 28 days leading to incomplete neurological accelerosis accompanied by partial irreversible hypersensitivity to adrenaline, while 5 mg/kg does not cause tissue or permanent blood flow force changes

296.39

C₁₀H₂₄N₄O₄S

645-43-2

固体

Solid

White to off-white

硫酸胍乙啶

Acetylene sulphate

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. Mitchell JR, et al. Antagonism of the antihypertensive action of guanethidine sulfate by desipramine hydrochloride. JAMA. 1967 Dec 4;202(10):973-6.  [Content Brief]

  [2]. Nielsen GD. Guanethidine induced sympathectomy in the adult rat. I. Functional effects following subacute administration. Acta Pharmacol Toxicol (Copenh). 1977 Sep;41(3):203-8.  [Content Brief]